Contrave is a prescription medication used for weight loss in adults. It combines two active ingredients, naltrexone and bupropion, to help reduce appetite and cravings.
While effective for weight management, some users experience side effects, including constipation. This article explores why Contrave causes constipation and how to manage it.
What Is Contrave and How Does It Work?
Contrave is approved by the FDA for adults with obesity or those overweight with weight-related health issues. It’s taken as an extended-release tablet, typically with a low-calorie diet and exercise.
Naltrexone, an opioid antagonist, reduces food cravings by blocking pleasure responses in the brain. Bupropion, an antidepressant, influences dopamine and norepinephrine to control appetite.
The combination targets the brain’s reward and hunger centers, like the hypothalamus. This helps users feel less hungry and crave fewer high-calorie foods.
However, these brain changes can also affect other bodily functions, including digestion. This is where side effects like constipation may come into play.
Common Side Effects of Contrave
Contrave can cause several side effects, especially during the first few weeks. Clinical trials show that about 19% of users report constipation, making it one of the top side effects. Other common issues include nausea, headache, dizziness, and trouble sleeping.
These side effects often lessen as the body adjusts to the medication. Constipation, however, can persist for some users, especially if not managed early.
Understanding why Contrave causes constipation starts with looking at how it affects the body.
Why Does Contrave Cause Constipation?
Constipation happens when bowel movements become infrequent or hard to pass. Contrave’s ingredients, naltrexone and bupropion, can slow down the digestive system. This slowdown reduces the movement of food through the intestines, leading to harder stools.
Bupropion, in particular, may affect the nervous system, which controls gut motility. By altering neurotransmitter activity, it can weaken the signals that push food through the digestive tract. Naltrexone may also contribute by influencing opioid receptors in the gut, further slowing digestion.
The Role of Dehydration and Diet
Contrave’s appetite-suppressing effects can lead to reduced food and water intake. If users eat less, they may consume fewer fiber-rich foods, which are key for healthy digestion. Low fiber intake can make stools harder and less frequent.
Drinking less water is another issue, as Contrave can make users feel full quickly. Dehydration makes stools dry and difficult to pass. Combining these factors with Contrave’s effects on the gut can worsen constipation.
How Contrave’s Dosing Schedule Impacts Constipation
Contrave is started at a low dose and gradually increased over four weeks. This slow increase helps the body adjust, but side effects like constipation may appear early. The first few weeks, when the dose is ramping up, are when constipation is most common.
By week four, users take two tablets twice daily, totaling 32 mg of naltrexone and 360 mg of bupropion. If constipation persists beyond this adjustment period, lifestyle changes or medical advice may be needed.
Who Is More Likely to Experience Constipation?
Not everyone taking Contrave will experience constipation. Those with a history of digestive issues, like irritable bowel syndrome or chronic constipation, may be more at risk. Older adults or people with slower metabolisms might also notice worse symptoms.
Diet and activity levels play a big role. Sedentary individuals or those with low-fiber diets are more likely to face constipation. Knowing these risk factors can help users take preventive steps early.
Managing Constipation While Taking Contrave
Constipation from Contrave is often manageable with simple changes. Staying proactive can reduce discomfort and improve digestion. Here are some practical tips to help:
- Drink plenty of water: Aim for 8–10 glasses daily to keep stools soft.
- Eat fiber-rich foods: Include fruits, vegetables, whole grains, and legumes.
- Stay active: Light exercise, like walking, can stimulate bowel movements.
- Consider OTC remedies: Stool softeners or mild laxatives may help, but consult a doctor first.
These steps can ease constipation and support overall health while on Contrave.
The Importance of Fiber in Your Diet
Fiber is crucial for preventing constipation. There are two types: soluble and insoluble. Soluble fiber, found in oats and apples, absorbs water to form a gel-like substance. Insoluble fiber, in whole grains and vegetables, adds bulk to stools.
Contrave users should aim for 25–30 grams of fiber daily. Gradually increasing fiber prevents bloating or gas. Pairing fiber with water ensures it works effectively to keep digestion smooth.
Table: Fiber-Rich Foods to Help Prevent Constipation
| Food | Serving Size | Fiber Content (grams) |
|---|---|---|
| Apple (with skin) | 1 medium | 4.5 |
| Broccoli | 1 cup, cooked | 5.0 |
| Lentils | 1/2 cup, cooked | 8.0 |
| Whole-grain bread | 1 slice | 2.0 |
| Chia seeds | 2 tablespoons | 10.0 |
This table shows examples of fiber-rich foods to include in your diet. Adding these gradually can help manage constipation while taking Contrave.
Exercise and Its Role in Digestion
Physical activity stimulates the muscles in the digestive tract. Even a 20-minute walk daily can promote regular bowel movements. Exercise also boosts overall metabolism, which may counteract some of Contrave’s slowing effects on the gut.
Activities like yoga or swimming are gentle yet effective. Staying consistent with movement supports both weight loss goals and digestive health. Always check with a doctor before starting a new exercise routine.
When to Talk to Your Doctor
Most cases of constipation from Contrave are mild and improve with lifestyle changes. However, persistent or severe constipation needs medical attention. Symptoms like blood in stools, severe pain, or no bowel movements for several days are red flags.
Your doctor may suggest over-the-counter treatments or adjust your Contrave dose. In rare cases, they might recommend stopping the medication if side effects are too severe.
Other Gastrointestinal Side Effects of Contrave
Constipation isn’t the only digestive issue Contrave can cause. Nausea affects about 33% of users, often early in treatment. Vomiting and diarrhea are less common but can also occur.
These side effects are usually temporary, fading as the body adapts. Managing them with small, bland meals and hydration can help. If digestive issues persist, a healthcare provider can offer guidance.
How Long Does Constipation Last?
Constipation from Contrave often starts in the first two weeks and may last a few weeks. For most users, it improves as the body adjusts to the medication. Reddit users report that constipation may take weeks or months to fully resolve for some.
Sticking to a high-fiber diet and staying hydrated can speed up relief. If symptoms don’t improve after a month, consult your doctor for personalized advice.
Serious Side Effects to Watch For
While constipation is common, Contrave has rare but serious side effects. These include seizures, liver damage, and increased blood pressure. The FDA includes a boxed warning for suicidal thoughts, especially in younger users.
If you notice symptoms like yellowing skin, severe mood changes, or uncontrolled movements, stop Contrave and call your doctor immediately. Regular monitoring by a healthcare provider is essential.
Lifestyle Tips for Better Weight Loss and Digestion
Contrave works best with a healthy lifestyle. Eating nutrient-dense foods like lean proteins, fruits, and vegetables supports weight loss and digestion. Avoiding high-fat or sugary foods reduces side effects and boosts results.
Staying hydrated and active also enhances Contrave’s effectiveness. These habits not only help with constipation but also improve overall well-being during weight loss.
Summary
Contrave is a weight loss medication that combines naltrexone and bupropion to curb appetite and cravings. While effective, it can cause constipation in about 19% of users due to its effects on the nervous system and gut motility.
Factors like low fiber intake, dehydration, and reduced activity can worsen this side effect. Managing constipation involves drinking water, eating fiber-rich foods, and staying active.
Most cases improve within weeks, but persistent symptoms require medical advice. By adopting healthy habits, users can reduce constipation and support their weight loss journey.
FAQ
Why does Contrave cause constipation?
Contrave’s ingredients, naltrexone and bupropion, slow gut motility by affecting the nervous system. This can lead to harder, less frequent stools. Low fiber and water intake may worsen the issue.
How can I prevent constipation while taking Contrave?
Drink 8–10 glasses of water daily and eat 25–30 grams of fiber from fruits, vegetables, and whole grains. Regular exercise, like walking, also helps. Consult your doctor before using laxatives.
How long does Contrave-related constipation last?
Constipation often starts in the first two weeks and may last a few weeks. It usually improves as your body adjusts. Persistent symptoms should be discussed with your doctor.
Are there serious side effects of Contrave I should know about?
Yes, rare side effects include seizures, liver damage, and increased blood pressure. Contrave also has a boxed warning for suicidal thoughts. Contact your doctor if you notice severe symptoms.
Can diet changes help with Contrave’s side effects?
Yes, eating fiber-rich foods and staying hydrated can ease constipation and nausea. Avoiding high-fat or sugary foods supports weight loss and reduces side effects. Always follow your doctor’s advice.