Naltrexone is a medication originally designed to treat opioid and alcohol addiction. In recent years, it has gained attention for its potential to aid weight loss.
This article explores the best dose of naltrexone for weight loss, how it works, and what to consider when using it.
What Is Naltrexone?
Naltrexone is an opioid receptor antagonist. It blocks the effects of opioids and alcohol in the brain. At lower doses, it shows promise for other uses, including weight management.
It’s available as a daily pill or a monthly injection. The brand names include Revia, Vivitrol, and Depade. For weight loss, it’s often combined with bupropion, another medication.
How Does Naltrexone Help with Weight Loss?
Naltrexone affects the brain’s reward system. It reduces cravings for high-calorie foods, like sugary or fatty snacks. This makes it easier to stick to a healthy diet.
When combined with bupropion, it also suppresses appetite. Bupropion boosts energy and stabilizes mood, supporting weight loss efforts. Together, they target both hunger and eating behaviors.
Low-Dose Naltrexone (LDN) vs. Standard Dose
Low-dose naltrexone (LDN) uses smaller amounts, typically 1.5 to 4.5 mg daily. Standard doses for addiction are 50 mg or higher. LDN is often explored for weight loss due to fewer side effects.
LDN may work by increasing endorphin levels. This can reduce inflammation and improve metabolism, indirectly aiding weight loss. Standard doses are less commonly used alone for this purpose.
Why Choose LDN for Weight Loss?
LDN is safer for long-term use. It has minimal side effects compared to higher doses. Many find it easier to tolerate.
It also supports lifestyle changes. By curbing food cravings, LDN helps maintain a calorie deficit. This is key for sustainable weight loss.
Best Dose of Naltrexone for Weight Loss
The best dose of naltrexone for weight loss depends on the individual. For LDN, 4.5 mg daily is commonly used. Some start at 1.5 mg and gradually increase.
When combined with bupropion, the FDA-approved drug Contrave uses 8 mg of naltrexone with 90 mg of bupropion. This is taken twice daily, totaling 16 mg of naltrexone.
Always consult a doctor to find the right dose. Factors like medical history and weight loss goals matter.
Dosage Table for Naltrexone in Weight Loss
| Form | Naltrexone Dose | Frequency | Notes |
|---|---|---|---|
| Low-Dose Naltrexone (LDN) | 1.5–4.5 mg | Once daily | Often used off-label, start low |
| Naltrexone/Bupropion (Contrave) | 8 mg per tablet | Two tablets, twice daily | FDA-approved, titrated over 4 weeks |
How to Take Naltrexone Safely
Naltrexone should be prescribed by a healthcare provider. For LDN, it’s typically taken at night to align with endorphin production. Contrave is taken with meals, starting with one tablet daily.
Avoid opioids while on naltrexone, as it blocks their effects. This includes pain medications like morphine. A 7–10 day opioid-free period is needed before starting.
Follow your doctor’s instructions closely. Never adjust the dose on your own.
Benefits of Naltrexone for Weight Loss
Naltrexone offers several advantages for weight management. Here are key benefits:
- Reduced Cravings: Lessens desire for unhealthy foods.
- Improved Diet Adherence: Makes it easier to follow a healthy eating plan.
- Mood Support: When paired with bupropion, it stabilizes mood, reducing emotional eating.
- Minimal Side Effects: LDN is generally well-tolerated.
Studies show Contrave users lose 5–10% of body weight over 52 weeks. This is significant for obese or overweight individuals.
Potential Side Effects
Naltrexone is safe for most, but side effects can occur. Common ones include nausea, headache, and dizziness. These often fade over time.
LDN has fewer side effects due to its lower dose. Contrave may cause constipation or vomiting in some users. Serious side effects, like liver issues, are rare but possible.
Report any unusual symptoms to your doctor. They may adjust the dose or switch medications.
Who Should Use Naltrexone for Weight Loss?
Naltrexone is best for overweight or obese adults. It’s often prescribed for those with a BMI of 27 or higher with conditions like diabetes. People who struggle with food cravings are good candidates.
It’s not suitable for everyone. Those with opioid dependence or liver disease should avoid it. Pregnant or breastfeeding women need medical guidance.
Lifestyle Changes to Boost Results
Naltrexone works best with lifestyle changes. A balanced diet and regular exercise are essential. Aim for a calorie deficit of 500–750 calories daily.
Behavioral changes also help. Practice mindful eating and track your food intake. These habits maximize naltrexone’s effects.
Risks and Precautions
Naltrexone can interact with other medications. It blocks opioid painkillers, which can complicate pain management. Always inform your doctor about all medications you take.
There’s a risk of opioid overdose if you relapse while on naltrexone. This is due to lowered opioid tolerance. Stay opioid-free during treatment.
Misusing naltrexone can lead to disordered eating. Use it only under medical supervision.
What Does Research Say?
Clinical studies support naltrexone’s role in weight loss. A 2016 review found Contrave led to 4.5 kg more weight loss than placebo. Over 50% of users lost at least 5% of their body weight.
LDN research is less extensive but promising. Small trials suggest it reduces appetite and supports metabolism. More studies are needed to confirm its efficacy.
How Long Does It Take to See Results?
Weight loss with naltrexone varies. Some notice changes in appetite within weeks. Significant weight loss often takes 3–6 months.
Contrave users may lose 5–10% of body weight in a year. Consistency with diet and exercise speeds up results. Patience is key, as progress can be gradual.
Cost and Accessibility
Naltrexone is prescription-only. Generic LDN is affordable, often costing $20–$50 monthly. Contrave is pricier, around $360 per month without insurance.
Insurance may cover Contrave for weight loss. Check with your provider for coverage details. Compounding pharmacies can prepare LDN at lower costs.
Combining Naltrexone with Other Treatments
Naltrexone pairs well with lifestyle interventions. Counseling or support groups can address emotional eating. Nutritionists can design meal plans to complement the medication.
Other weight loss drugs, like GLP-1 agonists, may be more effective for some. Discuss all options with your doctor to find the best approach.
Summary
Naltrexone is a promising tool for weight loss, especially when combined with bupropion in Contrave. The best dose of naltrexone for weight loss is typically 4.5 mg for LDN or 16 mg daily in Contrave.
It reduces cravings and supports healthy eating habits. Always use it under medical supervision, alongside diet and exercise, for optimal results. While effective, it’s not a magic pill—lifestyle changes are crucial.
FAQ
What is the best dose of naltrexone for weight loss?
For low-dose naltrexone (LDN), 4.5 mg daily is common. In Contrave, 16 mg of naltrexone (with bupropion) is taken daily. Consult your doctor for the right dose.
How does naltrexone help with weight loss?
Naltrexone reduces food cravings by affecting the brain’s reward system. When paired with bupropion, it also suppresses appetite, making it easier to eat less.
Are there side effects of naltrexone for weight loss?
Common side effects include nausea, headache, and dizziness. These are usually mild and fade over time. Serious side effects are rare but should be reported.
Who should not take naltrexone?
People using opioids, with liver disease, or pregnant women should avoid naltrexone. Always discuss your medical history with your doctor before starting.
How long does naltrexone take to work for weight loss?
Appetite changes may start within weeks. Significant weight loss often takes 3–6 months with consistent use, diet, and exercise.