Wegovy and Mounjaro are popular medications for weight loss and managing health conditions like diabetes. Both are effective, but their side effects can differ.
This article compares Wegovy vs Mounjaro side effects in simple terms. Let’s explore what you need to know to make informed choices.
What Are Wegovy and Mounjaro?
Wegovy, with the active ingredient semaglutide, is a GLP-1 receptor agonist. It’s approved for weight loss in adults with obesity or those overweight with related conditions. Taken as a weekly injection, it reduces appetite and promotes fullness. Wegovy also helps manage blood sugar in type 2 diabetes.
Mounjaro, containing tirzepatide, targets both GLP-1 and GIP receptors. It’s approved for weight loss and type 2 diabetes management, also given weekly. Mounjaro’s dual action often leads to greater weight loss. Both drugs have side effects, which we’ll compare to highlight differences.
How These Medications Work
Wegovy mimics the GLP-1 hormone, slowing digestion and reducing hunger. This helps you eat less and lose weight over time. It also stabilizes blood sugar, benefiting those with diabetes. Its effects are steady but may take weeks to show significant results.
Mounjaro combines GLP-1 and GIP hormone effects, making it more potent for weight loss. It slows stomach emptying and boosts insulin release, controlling appetite and blood sugar. This dual mechanism can lead to faster weight loss. However, it may also increase certain side effects.
Common Side Effects of Wegovy
Wegovy’s side effects are often mild and improve with time. Gastrointestinal issues are the most common, especially early in treatment. These occur as your body adjusts to slower digestion. Most people tolerate Wegovy well with proper dosing.
In clinical trials, like the STEP program, about 70% of Wegovy users reported side effects. The majority were digestive-related and manageable. Serious side effects are rare but possible. Knowing what to expect helps you prepare.
Common Wegovy Side Effects
- Nausea or vomiting
- Diarrhea or constipation
- Abdominal pain
- Fatigue or headache
These side effects typically lessen after a few weeks. If they persist, consult your doctor.
Common Side Effects of Mounjaro
Mounjaro shares many side effects with Wegovy due to similar mechanisms. Digestive issues dominate, often more intense because of Mounjaro’s dual hormone action. These effects are most noticeable when starting or increasing doses. They usually fade as your body adapts.
The SURMOUNT-1 trial reported side effects in about 80% of Mounjaro users. Most were mild, with nausea and diarrhea being the top complaints. Mounjaro’s stronger weight loss effect may amplify some side effects. Monitoring by your doctor ensures safety.
Common Mounjaro Side Effects
- Nausea or vomiting
- Diarrhea or stomach upset
- Decreased appetite
- Injection site reactions
Like Wegovy, these effects often improve over time. Persistent issues should be discussed with your healthcare provider.
Comparing Wegovy vs Mounjaro Side Effects
When comparing Wegovy vs Mounjaro side effects, digestive issues are the main overlap. Both drugs cause nausea, diarrhea, and abdominal discomfort, especially early on. However, Mounjaro users may experience these more frequently due to its dual hormone action. Wegovy’s side effects tend to be slightly milder.
Clinical data shows Mounjaro has a higher rate of gastrointestinal side effects. For example, 40% of Mounjaro users reported nausea compared to 30% on Wegovy. Serious side effects, like pancreatitis, are rare for both. The choice often depends on how your body responds.
Table: Wegovy vs Mounjaro Side Effects Comparison
| Side Effect | Wegovy (Semaglutide) | Mounjaro (Tirzepatide) |
|---|---|---|
| Nausea | 30% of users | 40% of users |
| Diarrhea | 16% of users | 23% of users |
| Vomiting | 10% of users | 13% of users |
| Constipation | 11% of users | 8% of users |
| Pancreatitis (serious) | <1% of users | <1% of users |
This table highlights the frequency of key side effects based on clinical trials. Individual experiences may vary, so consult your doctor.
Serious Side Effects to Watch For
Both drugs carry risks of rare but serious side effects. Pancreatitis, inflammation of the pancreas, is a concern for both Wegovy and Mounjaro. Symptoms include severe abdominal pain, nausea, and vomiting. If these occur, seek medical help immediately.
Gallbladder issues, like gallstones, are also possible. Wegovy has a slightly higher reported rate of gallbladder problems (2.6% vs. 1.8% for Mounjaro). Both drugs may increase thyroid tumor risk in rare cases, based on animal studies. Regular monitoring reduces these risks.
Eye-Related Side Effects
Recent studies raised concerns about eye issues, particularly nonarteritic anterior ischemic optic neuropathy (NAION). NAION causes sudden vision loss and has been linked to GLP-1 drugs. A 2024 study found a higher NAION risk with semaglutide (Wegovy) than tirzepatide (Mounjaro). However, the risk is still low.
Mounjaro may worsen diabetic retinopathy in some diabetic patients, though this is rare. Wegovy has similar reports but at a lower frequency. Regular eye exams are recommended for both drugs. Report vision changes to your doctor promptly.
Impact on Blood Sugar and Related Side Effects
Both Wegovy and Mounjaro lower blood sugar, which is great for diabetes management. However, this can cause side effects like dizziness or shakiness, especially if you’re on other diabetes medications. Mounjaro’s dual action may lead to stronger blood sugar drops, increasing these risks.
Hypoglycemia (low blood sugar) is rare but more likely with Mounjaro (6% vs. 3% for Wegovy in trials). Your doctor may adjust other medications to prevent this. Monitoring blood sugar levels is key, especially early in treatment.
Who’s at Risk for Side Effects?
People with pre-existing digestive issues, like irritable bowel syndrome, may face worse side effects. Those with a history of pancreatitis or gallbladder disease are at higher risk for serious issues. Diabetic patients need careful monitoring for blood sugar and eye-related side effects. Older adults may also experience stronger side effects.
Your health history influences how you tolerate these drugs. Share your full medical background with your doctor before starting. They’ll tailor the treatment to minimize risks.
Managing Side Effects Effectively
Starting with a low dose helps your body adjust to either drug. Wegovy begins at 0.25 mg, while Mounjaro starts at 2.5 mg, with gradual increases. Taking injections with food or at night may reduce nausea. Staying hydrated also helps with diarrhea or constipation.
If side effects persist, your doctor may pause dose increases or lower your dose. Lifestyle changes, like eating smaller meals, can ease digestive issues. Always follow your doctor’s guidance for safe use.
Long-Term Side Effects and Safety
Long-term data for both drugs is still emerging. Both appear safe for extended use when monitored by a doctor. Gastrointestinal side effects tend to decrease after the first few months. Serious risks, like pancreatitis, remain rare but require vigilance.
Weight loss benefits may outweigh side effects for many users. Both drugs improve heart health and blood sugar control over time. Regular checkups ensure side effects don’t outweigh benefits. Discuss long-term use with your doctor.
Choosing Between Wegovy and Mounjaro
The choice depends on your health goals and tolerance for side effects. Mounjaro often leads to greater weight loss but may cause more digestive issues. Wegovy’s side effects are slightly milder, but weight loss may be slower. Your doctor will consider your medical history.
Cost and insurance coverage also play a role. Both drugs are expensive without coverage, and availability can vary. Discuss both options with your healthcare provider to find the best fit. Personal response to side effects often guides the decision.
Summary
Comparing Wegovy vs Mounjaro side effects shows many similarities, with key differences. Both cause digestive issues like nausea and diarrhea, but Mounjaro’s effects are often more frequent due to its dual hormone action.
Serious risks, like pancreatitis or NAION, are rare for both but require monitoring. Wegovy may have a slightly higher risk of gallbladder issues, while Mounjaro poses a greater chance of low blood sugar.
Regular checkups, starting with low doses, and lifestyle adjustments help manage side effects. Your doctor can guide you based on your health needs and tolerance. Both drugs offer significant weight loss benefits, but understanding their side effects ensures safe use.
FAQ
Are Mounjaro’s side effects worse than Wegovy’s?
Mounjaro often causes more frequent digestive side effects, like nausea and diarrhea. About 40% of users report nausea compared to 30% for Wegovy. Serious side effects are rare for both.
Can Wegovy or Mounjaro cause vision problems?
Both drugs are linked to a rare condition called NAION, which can cause vision loss. Wegovy has a slightly higher reported risk. Regular eye exams are recommended.
How can I reduce nausea from Wegovy or Mounjaro?
Start with a low dose and take injections with food or at night. Eating smaller meals and staying hydrated can help. Consult your doctor if nausea persists.
Who should avoid Wegovy or Mounjaro due to side effects?
People with a history of pancreatitis, gallbladder disease, or severe digestive issues may need caution. Diabetic patients should monitor blood sugar and eye health. Discuss risks with your doctor.
Do side effects of Wegovy and Mounjaro go away?
Most digestive side effects, like nausea, lessen after a few weeks or months. Persistent or severe side effects should be reported to your doctor. Dose adjustments may help.