Does Trulicity Cause Constipation?

Dulaglutide, which you might know as Trulicity, is a medication used to treat type 2 diabetes along with diet and exercise.

While it is effective in managing diabetes, patients may experience side effects, one of which is constipation. Understanding whether Trulicity causes constipation, how common this side effect is, and ways to manage it is crucial for patients and healthcare providers alike.

In today’s article, we’ll discuss whether Trulicity causes constipation, exploring the reasons behind it, management strategies, and alternative approaches.

Understanding Trulicity

Trulicity is a glucagon-like peptide-1 (GLP-1) receptor agonist that helps to regulate blood sugar levels by enhancing the secretion of insulin and inhibiting the release of glucagon.

It also slows gastric emptying, which can increase feelings of fullness and potentially support weight loss. Administered via a once-weekly injection, Trulicity offers convenience and consistent glycemic control for patients managing type 2 diabetes.

Can Trulicity Cause Constipation?

The short answer is Yes.

Constipation is listed as one of the potential gastrointestinal side effects of Trulicity. Studies show that roughly 3.7% to 3.9% of individuals taking Trulicity experience constipation compared to 0.7% receiving a placebo. While this might seem like a small percentage, it’s important for individuals using Trulicity to be aware of this potential side effect.

This occurs because Trulicity slows down gastric emptying which means that food moves more slowly through the digestive tract. This helps control blood sugar and can make you feel full longer, which might help with weight loss. However, it can also cause constipation for some people.

If you experience persistent or severe constipation while taking Trulicity, it is important to consult with your healthcare provider for tailored advice and management strategies.

The exact mechanism by which Trulicity causes constipation isn’t fully understood, but several factors might contribute:

Factors Contributing to Constipation:

Reduced gastrointestinal motility: Trulicity can slow down the rate at which food moves through the intestines, leading to a buildup of waste material and difficulty passing stools.

Slowed digestion: Trulicity slows down the movement of food through the digestive tract. This allows the body to absorb more nutrients and regulate blood sugar effectively. However, the downside is that slower movement can lead to constipation.
Increased fluid absorption: Trulicity may increase the reabsorption of fluids from the intestines. This can lead to stool becoming harder and more difficult to pass.
Changes in gut bacteria: GLP-1 receptors are present in the gut and may influence the composition of gut bacteria. Some studies suggest that Trulicity might alter gut bacteria, potentially affecting bowel movements.

How can Manage Constipation While Taking Trulicity?

Constipation is a common side effect of Trulicity. If you experience constipation while using Trulicity, there are steps you can take to manage it:

Increase Fiber Intake: Aim for plenty of fruits, vegetables, and whole grains. These foods add bulk to your stool and promote smoother passage. Examples include fruits with skin (apples, pears), leafy greens (spinach, kale), and whole-wheat bread/pasta.
Hydration is Key: Drink plenty of fluids throughout the day, especially water. Aim for eight glasses daily. Water helps soften stool and makes it easier to pass.

Exercise: Regular physical activity can stimulate bowel movements. Aim for at least 30 minutes of moderate-intensity exercise most days of the week.
Over-the-counter Laxatives: Consider using over-the-counter laxatives for short-term relief. However, consult your doctor before using any laxatives, especially if you have underlying medical conditions.
Bulk-forming Laxatives: These medications add bulk to stool, promoting easier passage. Examples include psyllium (Metamucil) and polycarbophil (FiberCon).

Additional Tips:

Establish a Routine: Try to go to the bathroom at a similar time each day, even if you don’t feel the urge initially. This can help regulate your bowels over time.
Listen to Your Body: Don’t ignore the urge to have a bowel movement. Delaying it can make constipation worse.
Posture Matters: Proper positioning on the toilet can aid in smoother bowel movements. Consider using a squat stool for better positioning.

When to Talk to Your Doctor?

If constipation persists despite lifestyle modifications, or if you experience severe abdominal pain, rectal bleeding, or bloating, it’s crucial to talk to your doctor.

They can assess your situation, recommend alternative management strategies, or adjust your Trulicity dosage if necessary.

Alternative Approaches to Managing Type 2 Diabetes

If constipation with Trulicity proves particularly problematic, you and your doctor can discuss alternative approaches to managing type 2 diabetes. These might include:

Other GLP-1 Receptor Agonists: There are other GLP-1 receptor agonists available, and some might have a lower risk of causing constipation.
Injectable Medications: Other injectable medications for type 2 diabetes exist, such as SGLT2 inhibitors or DPP-4 inhibitors, which work differently and may not cause constipation.

Oral Medications: Certain oral medications can be used for type 2 diabetes, depending on the severity and individual factors.

Alternatives to Trulicity

There are other GLP-1 receptor agonist medications available for type 2 diabetes. Some, like Liraglutide (Victoza), may have a lower risk of constipation compared to Trulicity. However, this is a decision best made in consultation with your doctor, considering your individual needs and medical history.

Other Side Effects of Trulicity

Trulicity, while beneficial for type 2 diabetes management, can cause a range of side effects beyond constipation. Here’s a breakdown of some potential side effects:

Gastrointestinal:

Nausea and Vomiting: These are common side effects, especially when starting Trulicity. They usually subside over time.
Diarrhea: Similar to nausea and vomiting, diarrhea can occur but often improves with continued use.
Abdominal Pain: Stomach discomfort can be a side effect.

Indigestion/Heartburn: Trulicity might contribute to heartburn or indigestion.

General:

Fatigue: Feeling tired or lacking energy is a potential side effect.
Decreased Appetite: Trulicity can suppress appetite, which may lead to unintentional weight loss in some individuals.

Injection Site Reactions:

Redness, Swelling, or Pain: These mild reactions at the injection site are common and typically resolve on their own.

Serious Side Effects

Severe Allergic Reaction: Symptoms may include hives, swelling of the face, lips, tongue, or throat, and trouble breathing.
Pancreatitis: Inflammation of the pancreas can cause severe abdominal pain.

Gallbladder Problems: Trulicity may increase the risk of gallstones or inflammation of the gallbladder.
Slowed Heart Rate: In rare cases, Trulicity might cause a slow heart rate.
Kidney Problems: Changes in urination or kidney function can occur.

Vision Changes: Report any sudden changes in vision to your doctor.
Thyroid Cancer Risk: Trulicity carries a boxed warning about a potential increased risk of a specific type of thyroid cancer (medullary thyroid cancer).

Conclusion

In conclusion, while Trulicity can cause constipation as a side effect, there are various ways to manage and potentially prevent this issue. By staying informed, maintaining open communication with healthcare providers, and implementing healthy lifestyle habits, individuals can navigate the potential gastrointestinal effects of Trulicity effectively.

Understanding the potential side effects of medications like Trulicity is crucial for proactive management of health conditions.

FAQ

Can constipation from Trulicity be managed?

Yes, constipation caused by Trulicity can often be managed through dietary changes, increased fluid intake, and over-the-counter remedies. It is important to discuss any concerns with a healthcare provider.

Does Trulicity cause weight loss?

Trulicity is not a weight-loss medication. However, it may lead to weight loss as a side effect due to its appetite-suppressing properties.

Does Trulicity interact with other medications?

Yes, Trulicity can interact with other medications, especially other diabetes medications. Discuss all medications you take with your doctor before starting Trulicity.

How common is constipation as a side effect of Trulicity?

Constipation is a relatively common side effect of Trulicity, affecting a significant number of individuals who take this medication.

References

The official Trulicity website: https://trulicity.lilly.com/

Medical News Today. Trulicity (dulaglutide). https://www.medicalnewstoday.com/articles/326844#-What-is-Trulicity?

Does Trulicity Cause Constipation?

Understanding Trulicity