Contrave is a prescription medication used to help adults manage weight alongside diet and exercise. It combines naltrexone and bupropion to reduce appetite and cravings. While effective, it can cause side effects ranging from mild to serious.
This article explores Contrave side effects and offers practical tips to avoid or manage them.
What Is Contrave and How Does It Work?
Contrave is approved for adults with obesity or weight-related health issues. Naltrexone reduces cravings, while bupropion affects mood and appetite. Together, they help you eat less and stick to a healthy lifestyle. However, these changes can lead to side effects.
The medication is taken as a pill, with doses increasing gradually over weeks. This slow buildup helps your body adjust and minimizes side effects.
Understanding Contrave’s mechanism can prepare you for potential reactions. Always follow your doctor’s instructions for safe use.
Common Side Effects of Contrave
Most Contrave users experience mild side effects, especially during the first few weeks. These often improve as your body adapts.
Side effects can affect the digestive system, nervous system, or mood. Below are the most common ones reported in studies.
- Nausea: Affects about 32% of users, often early on.
- Headache: Occurs in roughly 18% of patients.
- Constipation: Impacts around 19% of users.
- Dizziness: Reported by 10% of patients.
- Insomnia: Noted in about 9% of users.
These side effects are usually temporary, lasting days to weeks. They may worsen during dose increases. If they persist, talk to your doctor.
Managing Common Contrave Side Effects
Simple lifestyle changes can help reduce common Contrave side effects. Adjusting your habits and medication routine can improve comfort. Here are effective ways to manage these issues.
Nausea
Nausea is the most frequent side effect, especially when starting Contrave. Take the medication with food to settle your stomach. Avoid greasy or spicy meals that can worsen nausea. Sip ginger tea or suck on ginger candies for relief.
Eat small, frequent meals to avoid overwhelming your stomach. If nausea continues, ask your doctor about taking Contrave at a different time of day. These steps can ease discomfort and keep you on track.
Headache
Headaches are common, particularly during dose increases. Stay hydrated by drinking 6–8 glasses of water daily to prevent dehydration-related headaches. Avoid caffeine or alcohol, which can trigger pain. Rest in a quiet, dark room if a headache occurs.
Over-the-counter pain relievers like ibuprofen can help, but check with your doctor first. If headaches are frequent or severe, your dose may need adjustment. Tracking headache triggers can also guide prevention.
Constipation
Constipation can occur as your body adjusts to Contrave. Eat high-fiber foods like fruits, vegetables, and whole grains to promote bowel movements. Drink plenty of water to soften stools. A daily walk or light exercise can stimulate digestion.
If needed, ask your pharmacist about a gentle laxative. Avoid long-term laxative use without medical advice. These changes can relieve constipation and improve comfort.
Dizziness
Dizziness may happen, especially when standing up quickly. Rise slowly from sitting or lying positions to prevent lightheadedness. Stay hydrated and eat regular meals to maintain stable blood sugar. Avoid driving or operating machinery if you feel dizzy.
If dizziness persists, inform your doctor, as it may signal low blood pressure or another issue. They may adjust your dose or check for other causes.
Insomnia
Insomnia can disrupt sleep, especially if Contrave is taken late in the day. Take your dose in the morning to avoid nighttime stimulation. Avoid caffeine or heavy meals close to bedtime. Create a relaxing bedtime routine, like reading or meditating.
If sleep problems continue, discuss timing or dose adjustments with your doctor. Avoid sleep aids unless prescribed. Consistent sleep habits can reduce insomnia.
Serious Side Effects to Watch For
Contrave can cause rare but serious side effects that need immediate attention. These are uncommon but can be dangerous if ignored. Knowing the warning signs helps you act quickly.
Seizure Risk
Contrave carries a boxed warning for seizure risk due to bupropion. Seizures are rare but more likely at higher doses or in those with a seizure history. Avoid alcohol, recreational drugs, or certain medications that lower the seizure threshold.
Symptoms include sudden convulsions, confusion, or loss of consciousness. Seek emergency help if a seizure occurs. Discuss your medical history with your doctor to assess this risk.
Suicidal Thoughts or Mood Changes
Bupropion can increase the risk of suicidal thoughts or behavior, especially in younger adults or those with depression. Mood changes, anxiety, or agitation may also occur. Monitor your mental health closely when starting Contrave.
Tell your doctor immediately if you notice worsening mood or suicidal thoughts. Family members should watch for unusual behavior. Regular check-ins with your doctor can help manage this risk.
High Blood Pressure
Contrave can raise blood pressure or heart rate, especially in those with heart conditions. Symptoms include headaches, chest pain, or shortness of breath. Monitor your blood pressure regularly as directed by your doctor.
Avoid stimulants like caffeine or decongestants, which can worsen this issue. Report any concerning symptoms to your doctor promptly. Lifestyle changes like a low-sodium diet can help.
Liver Problems
Rarely, Contrave may cause liver damage. Symptoms include yellowing of the skin or eyes, dark urine, or severe fatigue. Those with liver disease or heavy alcohol use are at higher risk.
Avoid excessive alcohol and report unusual symptoms to your doctor immediately. Regular liver function tests may be recommended. Early detection prevents complications.
Allergic Reactions
Severe allergic reactions to Contrave are rare but possible. Symptoms include rash, swelling, or trouble breathing. These require immediate medical attention.
If you have a history of allergies, discuss Contrave with your doctor before starting. Keep emergency contact information handy. Quick action can be lifesaving.
Table: Common vs. Serious Contrave Side Effects
| Side Effect | Frequency | Symptoms | Management Tips |
|---|---|---|---|
| Nausea | Common (32%) | Upset stomach, feeling sick | Take with food, eat bland meals, use ginger |
| Headache | Common (18%) | Head pain, pressure | Stay hydrated, use pain relievers, rest |
| Seizures | Rare | Convulsions, confusion | Seek emergency help, avoid alcohol |
| Suicidal Thoughts | Rare | Mood changes, depression | Monitor mood, contact doctor immediately |
| High Blood Pressure | Rare | Chest pain, shortness of breath | Monitor blood pressure, avoid stimulants |
This table compares common and serious Contrave side effects, their symptoms, and management strategies. Always consult your doctor for personalized guidance.
Tips to Minimize Contrave Side Effects
Proactive steps can reduce the likelihood of Contrave side effects. These focus on lifestyle and medication management. Following them can make your treatment smoother.
Follow your doctor’s dosing schedule, starting with a low dose. Gradual increases over four weeks help your body adjust. Never take more than prescribed, as this raises seizure risk.
Eat a balanced diet with lean proteins, vegetables, and whole grains. Avoid heavy or processed foods that can upset your stomach. Small, frequent meals are easier to digest.
Drink 6–8 glasses of water daily to stay hydrated. Limit alcohol and caffeine, which can worsen side effects like dizziness or insomnia. Hydration supports overall health.
Incorporate light exercise, like a 20-minute walk, to boost mood and digestion. Avoid intense workouts during dose increases. Exercise supports weight loss and reduces constipation.
Keep a symptom journal to track side effects and their triggers. Share this with your doctor to adjust your treatment. Open communication ensures the best results.
Who Should Avoid Contrave?
Contrave isn’t safe for everyone. Certain conditions or risks make it unsuitable. Discuss these with your doctor before starting.
People with a history of seizures or eating disorders like bulimia should not use Contrave. The seizure risk makes it dangerous. Those allergic to naltrexone or bupropion should also avoid it.
Pregnant or breastfeeding women should not take Contrave. It may harm a fetus or pass into breast milk. Discuss alternative options with your doctor if planning pregnancy.
If you have uncontrolled high blood pressure, liver disease, or opioid use, Contrave may not be safe. These conditions increase the risk of serious side effects. Share your full medical history.
When to Contact Your Doctor
Most Contrave side effects are mild, but some require urgent care. Knowing when to seek help is critical. Don’t ignore severe or unusual symptoms.
Contact your doctor if nausea, headaches, or constipation last beyond a few weeks. They may adjust your dose or suggest remedies. Persistent dizziness or insomnia also needs evaluation.
Seek immediate help for seizures, suicidal thoughts, or allergic reactions. Symptoms like chest pain, severe mood changes, or yellowing skin require emergency attention. Act quickly to stay safe.
Regular checkups help monitor your health. Report new or worsening symptoms during visits. Staying proactive keeps your treatment effective and safe.
Summary
Contrave is an effective weight loss medication, but it comes with potential side effects. Common issues like nausea, headaches, and constipation are usually mild and temporary.
Serious side effects, such as seizures or suicidal thoughts, are rare but require immediate attention.
By following a balanced diet, staying hydrated, and adhering to your doctor’s dosing plan, you can minimize Contrave side effects.
Consult your healthcare provider for guidance and report concerning symptoms promptly.
FAQ
What are the most common Contrave side effects?
Nausea, headaches, constipation, dizziness, and insomnia are most common. They affect 9–32% of users, often early in treatment. These usually improve within weeks.
How can I reduce nausea from Contrave?
Take Contrave with food and eat small, bland meals. Avoid spicy or greasy foods and try ginger tea. Consult your doctor if nausea persists.
Are there serious risks with Contrave?
Rare risks include seizures, suicidal thoughts, and high blood pressure. Seek immediate help for convulsions, mood changes, or chest pain.
How do I manage constipation on Contrave?
Eat fiber-rich foods, drink plenty of water, and exercise daily. A mild laxative may help, but check with your pharmacist first.
Who should not use Contrave?
Avoid Contrave if you have seizures, eating disorders, or are pregnant. Discuss high blood pressure or liver issues with your doctor.