Contrave is a prescription medication used for weight loss in adults who are obese or overweight with health conditions. It combines naltrexone and bupropion to reduce appetite and cravings.
The first week on Contrave can bring side effects as your body adjusts. This article explains Contrave side effects first week, how to manage them, and tips for a smooth start.
Understanding Contrave and Its Purpose
Contrave targets brain areas that control hunger and pleasure from eating. Naltrexone blocks opioid effects, while bupropion acts as an antidepressant to curb appetite. This duo helps you eat less and lose weight when paired with diet and exercise.
It’s taken as an extended-release tablet, starting with a low dose. The first week is crucial as your body gets used to the medication. Knowing what to expect can ease the transition.
How Contrave Is Dosed in the First Week
In the first week, you typically take one Contrave tablet (8 mg naltrexone/90 mg bupropion) each morning. This gradual start helps reduce side effects. Your doctor may increase the dose weekly, up to two tablets twice daily by week four.
Take Contrave with a low-fat meal to avoid stomach upset. Never crush or chew the tablet, as it’s designed for slow release. Follow your doctor’s instructions closely.
Common Side Effects in the First Week
Contrave side effects first week are often mild and temporary. About one in three people experience nausea, the most common issue. Other frequent side effects include headaches, constipation, and dizziness.
These effects usually lessen as your body adjusts. Clinical trials show nausea affects 32.5% of users, while headaches and constipation occur in about 18–19%. Staying proactive can help manage discomfort.
Most Common First-Week Side Effects
- Nausea or vomiting
- Headaches
- Constipation
- Dizziness or lightheadedness
Managing Nausea and Vomiting
Nausea is the top reason some stop Contrave early. To reduce it, take Contrave with a small, low-fat meal, like toast or crackers. Avoid greasy or spicy foods, which can worsen symptoms.
Eating smaller, frequent meals helps. If nausea persists, talk to your doctor about over-the-counter remedies. Staying hydrated also eases stomach discomfort.
Dealing with Headaches
Headaches affect about 17.6% of Contrave users in the first week. Drinking plenty of water can prevent dehydration-related headaches. A consistent sleep schedule also helps.
Over-the-counter pain relievers like ibuprofen may offer relief. If headaches are severe or frequent, consult your doctor. They may adjust your dose or suggest other solutions.
Coping with Constipation
Constipation, reported by 19.2% of users, can start in the first week. Increase fiber intake gradually with foods like fruits, vegetables, or whole grains. Drinking 8–10 glasses of water daily supports digestion.
Regular movement, like walking, can help. If constipation doesn’t improve, ask your doctor about over-the-counter laxatives. Avoid sudden fiber spikes to prevent bloating.
Addressing Dizziness and Fatigue
Dizziness or fatigue may occur as your body adjusts to Contrave. These effects are usually mild and fade within days. Avoid driving or operating machinery if you feel lightheaded.
Rest when needed and stay hydrated. If dizziness persists or worsens, contact your doctor. They’ll check for underlying causes, like low blood pressure.
Less Common Side Effects to Watch For
Some people experience dry mouth, insomnia, or mild anxiety in the first week. Dry mouth can be managed with sugar-free gum or frequent sips of water. Insomnia may improve with a bedtime routine, avoiding caffeine late in the day.
If anxiety feels overwhelming, talk to your doctor. These side effects are less frequent but can disrupt your routine if not addressed.
Serious Side Effects to Monitor
Serious side effects are rare but possible. Contrave has a boxed warning for suicidal thoughts, especially in younger adults. Watch for mood changes, irritability, or depression.
Other serious risks include seizures, allergic reactions, or increased blood pressure. Stop Contrave and seek medical help if you notice severe symptoms like rash, chest pain, or seizures.
Warning Signs Requiring Immediate Attention
- Suicidal thoughts or mood changes
- Seizures or shaking
- Severe allergic reactions (rash, swelling, trouble breathing)
- Chest pain or rapid heartbeat
Sample First-Week Symptom Tracker
Tracking symptoms helps you and your doctor understand Contrave’s effects. Note side effects, their severity, and any management steps. This can guide dose adjustments or treatment changes.
| Day | Side Effect | Severity (1–10) | Management | Notes |
|---|---|---|---|---|
| Day 1 | Nausea | 4 | Ate toast, drank water | Felt better by evening |
| Day 3 | Headache | 5 | Took ibuprofen | Slept well, less intense |
| Day 5 | Constipation | 3 | Added fiber, walked | Improved by Day 6 |
Tips to Minimize Side Effects
Taking Contrave correctly reduces side effects. Always take it with a low-fat meal, as high-fat meals increase seizure risk. Stay hydrated to ease nausea, constipation, and headaches.
Avoid alcohol, as it heightens seizure risk and worsens side effects. Tell your doctor about all medications, as some interact with Contrave. These steps make the first week smoother.
Lifestyle Support for a Better Start
A healthy lifestyle supports Contrave’s effectiveness and reduces side effects. Eat a balanced, low-calorie diet to aid weight loss. Include lean proteins, vegetables, and whole grains.
Exercise lightly, like 20-minute walks, to boost mood and digestion. Get 7–9 hours of sleep to combat fatigue. These habits help your body adjust to Contrave.
Working with Your Doctor
Your doctor is key to managing Contrave side effects first week. Share all symptoms during follow-ups, especially serious ones like mood changes. They may adjust your dose or suggest alternatives.
Bring a list of current medications to avoid interactions. Regular check-ins ensure Contrave is safe and effective. Open communication leads to better outcomes.
Emotional and Mental Health Monitoring
Bupropion in Contrave can affect mood, especially in the first week. Pay attention to feelings of anxiety, irritability, or sadness. Ask family or friends to watch for changes.
If you have a history of depression, discuss it with your doctor before starting. Call 911 or the 988 Lifeline if you experience suicidal thoughts. Staying vigilant protects your mental health.
What to Expect After the First Week
Most side effects lessen after the first week as your body adapts. Nausea and headaches often fade, though constipation may persist. Your doctor may increase your dose in week two, which could bring mild symptoms again.
Continue tracking symptoms and lifestyle habits. If side effects don’t improve by week two, consult your doctor. They’ll assess if Contrave is right for you.
Building a Support System
Starting Contrave can feel challenging, especially with side effects. Share your journey with trusted friends or family for encouragement. Join an online weight loss group for tips and motivation.
Support keeps you accountable and boosts morale. Celebrate small wins, like managing nausea or sticking to your diet. A positive mindset helps you push through the first week.
Long-Term Considerations
Contrave is meant for long-term use with diet and exercise. After 12 weeks, you should lose at least 5% of your starting weight. If not, your doctor may stop the medication.
Side effects often decrease over time, but some, like constipation, may linger. Keep up healthy habits to maintain weight loss. Regular doctor visits ensure ongoing safety.
Summary
Contrave side effects first week, like nausea, headaches, constipation, and dizziness, are common but manageable.
Take Contrave with low-fat meals, stay hydrated, and follow your doctor’s dosing plan. Track symptoms, avoid alcohol, and watch for serious issues like mood changes or seizures.
Pair Contrave with a healthy diet, exercise, and support system for the best results. With patience and care, you can navigate the first week and work toward your weight loss goals.
FAQ
How long do Contrave side effects last in the first week?
Most side effects, like nausea and headaches, last a few days and lessen as your body adjusts. Some, like constipation, may persist. Talk to your doctor if symptoms don’t improve.
Can I drink alcohol while starting Contrave?
Avoid alcohol, as it increases seizure risk and worsens side effects. Stick to water or unsweetened teas. Ask your doctor for specific advice.
What should I do if I miss a Contrave dose?
Take the missed dose as soon as you remember, unless it’s close to your next dose. Don’t double up. Contact your doctor for guidance.
Are Contrave side effects worse at higher doses?
Higher doses, starting in week two, may cause stronger side effects. Gradual dose increases help your body adjust. Report severe symptoms to your doctor.
Can I stop Contrave if side effects are bad?
Don’t stop without consulting your doctor, as abrupt changes can cause issues. They may adjust your dose or suggest alternatives. Always follow medical advice.