Does Jardiance Cause Weight Loss?

Jardiance (empagliflozin) is a medication primarily used to manage type 2 diabetes. Many patients notice a side effect: weight loss.

This article explores whether Jardiance causes weight loss, how it works, and what to expect.

Written in simple language, it breaks down the science and practical tips for those considering this medication.

What Is Jardiance?

Jardiance is a prescription drug for adults and children aged 10 and older with type 2 diabetes.

It belongs to a class of medications called sodium-glucose cotransporter-2 (SGLT2) inhibitors. It’s also approved to reduce cardiovascular risks and manage heart failure. Its active ingredient, empagliflozin, helps control blood sugar levels.

How Does Jardiance Work?

Jardiance works by targeting the kidneys. It blocks SGLT2 proteins, which normally reabsorb glucose back into the bloodstream. By stopping this process, Jardiance allows excess glucose to leave the body through urine. This mechanism lowers blood sugar and may contribute to weight loss.

Does Jardiance Cause Weight Loss?

Yes, Jardiance can lead to weight loss in many patients. While not FDA-approved for weight loss, studies show it causes modest weight reduction.

On average, patients lose 2-5% of their body weight. This effect is more pronounced when combined with lifestyle changes.

The Science Behind Jardiance and Weight Loss

Jardiance’s weight loss effect comes from its unique action. Each gram of glucose contains about 4 calories. By excreting 60-100 grams of glucose daily, Jardiance removes 240-400 calories from the body. Over time, this caloric deficit can lead to weight loss.

Caloric Loss Through Urine

When Jardiance prevents glucose reabsorption, the body loses calories through urine. This process doesn’t affect appetite or digestion. It’s a passive way to reduce calorie intake. Patients may notice gradual weight loss over weeks or months.

Reduction in Visceral Fat

Jardiance may reduce visceral fat, the harmful fat around internal organs. Studies suggest it decreases abdominal fat, lowering risks of heart disease and diabetes complications. This targeted fat loss is a significant health benefit. It’s not just about the number on the scale.

Mild Diuretic Effect

Jardiance has a mild diuretic effect, increasing urination. This can lead to initial water weight loss, especially in the first few weeks. While not fat loss, it contributes to early weight changes. Staying hydrated is key to managing this effect.

Clinical Evidence on Weight Loss

Clinical studies provide clear evidence of Jardiance’s weight loss effects. A 2014 study in Diabetes Care found patients lost 2.8-3.2% of their body weight after 24 weeks. Another study showed up to 8.8 pounds lost over 104 weeks. These results were compared to minimal weight loss in placebo groups.

Weight Loss with Combination Therapy

Jardiance works well with other diabetes medications like metformin. In a 24-week study, patients combining Jardiance and metformin saw greater weight loss than those using Jardiance alone. A diabetes-friendly diet and exercise can further boost results.

Long-Term Weight Loss

Weight loss with Jardiance is gradual but sustainable. Patients may lose about 1 pound per week with consistent use. Over 6-9 months, the full weight loss effect becomes noticeable. Long-term use maintains these benefits without significant weight regain.

Factors That Influence Weight Loss

Not everyone loses the same amount of weight with Jardiance. Several factors play a role in how much weight you might lose. Understanding these can help set realistic expectations.

• Diet: A balanced, low-sugar diet enhances weight loss.
• Exercise: Regular physical activity boosts caloric burn.
• Baseline Weight: Heavier individuals may lose more weight.
• Other Medications: Some diabetes drugs, like insulin, may counteract weight loss.

Comparing Jardiance to Other Diabetes Medications

Jardiance isn’t the only diabetes drug linked to weight loss. Medications like Ozempic (semaglutide) and Trulicity (dulaglutide) also promote weight reduction. However, they work differently, often by suppressing appetite. Jardiance’s weight loss is less dramatic but doesn’t involve appetite changes.

Jardiance vs. Ozempic

Ozempic, a GLP-1 receptor agonist, can lead to 12-15 pounds of weight loss in six months. Jardiance typically results in 4-6 pounds over the same period. Ozempic requires weekly injections, while Jardiance is a daily pill. Your doctor can help decide which is best for you.

Jardiance vs. Metformin

Metformin, another common diabetes drug, also promotes modest weight loss. In studies, Jardiance slightly outperforms metformin in weight reduction. Combining the two can enhance results. Always consult your doctor before combining medications.

Jardiance Weight Loss Table

Who Can Benefit from Jardiance?

Jardiance is primarily for people with type 2 diabetes. It’s especially helpful for those who are overweight or obese. About 90% of newly diagnosed type 2 diabetes patients are above their ideal weight. Jardiance can support both blood sugar control and weight management.

Not for Weight Loss Alone

Jardiance isn’t approved for weight loss in people without type 2 diabetes. Doctors may prescribe it off-label for weight loss, but this is rare. It’s not suitable for those with type 1 diabetes or severe kidney issues. Always discuss with your doctor before starting Jardiance.

Side Effects to Watch For

Like all medications, Jardiance has side effects. Most are mild, but some require attention. Knowing these can help you use Jardiance safely.

• Urinary Tract Infections (UTIs): Increased glucose in urine can lead to UTIs.
• Yeast Infections: More sugar in urine may cause genital yeast infections.
• Dehydration: Increased urination can cause fluid loss, so stay hydrated.
• Low Blood Pressure: Jardiance may lower blood pressure, especially in older adults.

Serious Side Effects

Rare but serious side effects include diabetic ketoacidosis and Fournier’s gangrene. These require immediate medical attention. Symptoms like fever, severe genital pain, or dizziness should prompt a call to your doctor. Regular monitoring can prevent complications.

Tips to Maximize Weight Loss with Jardiance

To get the most out of Jardiance, combine it with healthy habits. These steps can enhance weight loss and improve overall health.

• Eat a Balanced Diet: Focus on low-carb, high-fiber foods.
• Stay Active: Aim for 150 minutes of moderate exercise weekly.
• Stay Hydrated: Drink plenty of water to prevent dehydration.
• Monitor Blood Sugar: Regular checks ensure Jardiance is working effectively.

Lifestyle Changes for Better Results

Jardiance works best when paired with lifestyle changes. A diabetes-friendly diet, rich in vegetables and lean proteins, supports weight loss. Regular exercise, like walking or swimming, burns extra calories. Consistency is key to seeing results.

Other Benefits of Jardiance

Beyond weight loss, Jardiance offers significant health benefits. It lowers the risk of cardiovascular death by 38% in patients with type 2 diabetes and heart disease. It also reduces hospitalization for heart failure by 25%. Jardiance slows kidney disease progression, a common diabetes complication.

Blood Pressure Reduction

Jardiance can lower systolic blood pressure by 2-4 mmHg. This isn’t its primary purpose, but it’s a helpful side effect. People with type 2 diabetes are twice as likely to have high blood pressure. Jardiance’s diuretic effect supports this benefit.

Kidney Protection

Jardiance reduces the risk of kidney disease worsening. In a study, it lowered the risk of new or worsening kidney disease in patients with type 2 diabetes and heart disease. This makes it a valuable option for long-term health.

Is Jardiance Right for You?

Deciding if Jardiance is right depends on your health goals. If you have type 2 diabetes and want to manage blood sugar and lose weight, it’s worth considering. Discuss your medical history with your doctor. They’ll assess if Jardiance fits your needs.

Consulting Your Doctor

Your doctor will consider your kidney function, other medications, and overall health. Jardiance isn’t suitable for everyone, especially those with severe kidney issues or type 1 diabetes. Open communication ensures the best treatment plan.

Summary

Jardiance can cause weight loss as a side effect, typically 2-5% of body weight. It works by excreting glucose through urine, reducing calories and visceral fat. While not a weight loss drug, it benefits those with type 2 diabetes who are overweight. Combining Jardiance with a healthy diet and exercise maximizes results. It also offers heart and kidney benefits. Always consult your doctor to ensure Jardiance is safe for you.

FAQ

Can Jardiance be used for weight loss without diabetes?

Jardiance isn’t FDA-approved for weight loss alone. It’s primarily for type 2 diabetes. Doctors may prescribe it off-label, but this is uncommon. Consult your doctor for alternatives if weight loss is your goal.

How much weight can I lose with Jardiance?

Most patients lose 4-6 pounds over six months. Some lose up to 8.8 pounds over two years. Results vary based on diet, exercise, and baseline weight.

Does Jardiance suppress appetite?

No, Jardiance doesn’t affect appetite or digestion. Weight loss comes from excreting glucose, not reduced food intake. It’s different from drugs like Ozempic, which suppress appetite.

Are there risks to taking Jardiance for weight loss?

Common side effects include UTIs and yeast infections. Rare risks include dehydration and ketoacidosis. Stay hydrated and monitor symptoms to minimize risks.

How long does it take to see weight loss with Jardiance?

Initial water weight loss may occur within six weeks. Full weight loss effects take 6-9 months. Consistent use and healthy habits improve results.